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2020;6:eaay5366

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CB6F1 female mice were obtained from the National Institute on Aging aged rodent colony at 15 months of age

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It was originally developed as an anti-obesity drug , hence the name: Advanced Obesity Drug-9604

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Jardiance and GLP-1s are the rowboat and the speedboat of metabolic medication

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The PIONEER 4 trial showed that oral semaglutide was noninferior to liraglutide (another GLP-1 receptor agonist) for HbA1c reduction but superior for weight loss, and superior to placebo for both outcomes

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